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Mushroom bioactive peptides (MBPs) represent an underutilized yet highly promising reservoir of natural therapeutics, acting as a crucial biochemical bridge between traditional mycology and modern molecular pharmacology. While scientific literature has historically concentrated on animal- and plant-derived proteins, emerging research highlights that both edible and medicinal mushrooms function as sophisticated biological factories capable of yielding short-sequence amino acid chains (typically under 10 kDa) with exceptional structural diversity. Standardized screening libraries and repository frameworks, such as the BioPepDB Repository or the Data Repository of Antimicrobial Peptides (DRAMP), actively document these unique sequences from species like Ganoderma lucidum and Hericium erinaceus. These repositories map specific peptide configurations to their verified mechanisms of action, revealing critical health-promoting properties that include antioxidant, antihypertensive, immunomodulatory, and antimicrobial behaviors. By computational filtering and mapping these fungal fragments, these databases provide researchers with the exact sequence data needed to bypass traditional small-molecule limitations, paving the way for targeted applications in functional food design, clinical drug discovery, and natural disease prevention. [1, 2, 3, 4, 5, 6, 7, 8]